Home › Words › U › unfamiliarityunfamiliarityunfamiliarity means lack of familiarity; ignorance or inexperience.EtymologyFrom un- + familiarity.nounLack of familiarity; ignorance or inexperience.e.g.“Due to my unfamiliarity with the library's catalog system, it took several hours to find the book.”Definitions & examples from Wiktionary (CC BY-SA 3.0).