monobodyEtymologyFrom mono- + body. Coined in 1998 by the Koide group, who published the first paper demonstrating the concept.monobody means A synthetic binding protein constructed using a fibronectin type III domain as a molecular scaffold. Lexicurio rates it Sui generis — a strength score of 87 out of 100.nounA synthetic binding protein constructed using a fibronectin type III domain as a molecular scaffold.