Etymology
Most likely from the Cherokee autonym ᏣᎳᎩ (tsalagi). Derivation from a Choctaw exonym meaning "those who live in caves" (compare chiluk (“cave”)) has also been suggested — the Iroquois term for the Cherokee was Oyata'ge'ronon (“inhabitants of the cave country”) — as has derivation from a Creek term for "person(s) who speak(s) a non-Creek language" (see celokketv (“to speak a non-creek language”)). Regardless of its origin, the ethnonym entered European languages at an early date, perhaps as early as the 1670s; in Spanish, the people are called the Tchalaquei as early as 1755.
Definitions & examples from Wiktionary (CC BY-SA 3.0).